CURRICULUM VITAE

Personal data:

Name:   Eman Yassien Soliman Shoeib                    

Current position:   Assistant Professor of Medical Parasitology, Parasitology department-  Faculty of Medicine- Cairo University.

Phone: 01005477687 

E-Mail: eyshoeib@kasralainy.edu.eg

Administrative positions in Parasitology department:

Title of the (M. Sc) thesis: “Identification and Quantitation of House Dust Mites in Dwellings of Asthmatic Children”.

Title of the (M. D-PhD) thesis: “Biochemical and Genetic Studies on Some Species of the Medically Important House Dust Mites”.

Educational background:

M.B. B.ch: Cairo University  , Egypt, December 1994-1995       .

M. Sc:                 Cairo University, (Basic medical sciences) (November 2000)       

                           1St part: Medical Microbiology& Immunology

                           2nd part: Medical Parasitology

M.D:                  Medical Parasitology ( May 2005 )        

Professional Experiences:

•             House officer: from March1995  to March 1996, Cairo University hospitals (Kaser El Ainy)

•             Demonstrator (4-12-1996 to 29-5-2001), Parasitology  department, Faculty of Medicine, Cairo University.

•             Assistant lecturer (29-5-2001  to 26-10- 2005  ),Parasitology department, Faculty of   Medicine, Cairo  University.

•             Lecturer (26-10-2005  to 30-9- 2013  ),Parasitology   department, Faculty  of Medicine, Cairo University.                       

•             Assistant professor (30-9- 2013  to Now  ),Parasitology department, Faculty  of Medicine, Cairo University.

Teaching Experiences:

Courses: 

o             Laboratory demonstration & Practical course to medical students, Cairo University (1997 to 2014).

o             Teaching the Parasitology Practical course to under gradate medical students, Cairo University (1998 to 2014).

o             Sharing in teaching the Parasitology curriculum to post graduate students of clinical pathology, Tropical medicine& Public health, Cairo University for M.Sc degree (1999 to 2014).

o             Sharing in teaching the Parasitology practical course to under graduate medical students, Fayoum University

o             Sharing in teaching the Parasitology course to under graduate (Technical Institute) , Moubarak kohl Center, Cairo University. 

o             Sharing in teaching the Parasitology lectures, practical course, training laboratory Course, staining procedures & mounting procedures of Parasitology specimens to post graduate students of Parasitology dept. Cairo University for M.D degree (2001 to 2014).

o             Sharing in teaching the Parasitology lectures, practical course, training laboratory Courses to post graduate students of Parasitology dept. Ophthalmology Institute, Tropical medicine and Hepatology institute &the other Institutes related to Cairo University for M.D degree (2001 to 2014).

o             Sharing in teaching the Parasitology lectures, in Tropical Medicine Summer School August 2008& February 2008  Students’Scientific Society “SSS”.

Training courses:

o             Training course on Medical education & evaluation, Cairo University .

o             Computer course at  Cairo University

o             Course & workshop  on  medical education: curriculum development,evaluation   Pr.Dr. Nigel Bax& Pr.Dr.Pasty Stark , workshop in  Faculty of Medicine, Cairo University 1-6-2009 to 2-6-2009.

o             Course & workshop on “technology use in teaching” (Faculty and leader ship development project), Faculty of Medicine, Cairo University 27-4-2009 to 29-4-2009.

o             Course & workshop on  “Publishing”  (Faculty and leader ship development project, Faculty of Medicine, Cairo University 8-3-2010 to 10-3-2010.

o             Course & workshop on  “How to compete for a research fund”  (Faculty and leader ship development project, Faculty of Medicine, Cairo University18-4-2011 to 20-4-2011.

o             Course & workshop on “Code of ethics” (Faculty and leader ship development project, Faculty of Medicine, Cairo University) 18-7-2011 to 20-7-2011.

o             Course & workshop on “Communication skills” (Faculty and leader ship development project, Faculty of Medicine, Cairo University) 16-1-2012 to 18-1-2012.

o             Course & workshop on “Legal& financial aspects in university environment” (Faculty and leader ship development project, Faculty of Medicine, Cairo University) 25-9-2012 to 27-9-2012.

o             Course & workshop on “How to get published in prestigious journals”

( Faculty of Medicine, Cairo University MEDC) 9-3-2014.

- Effect of Chemotherapy with praziquantel on endogenous interleukin 12 (IL-12) in Schistosoma mansoni infection in mice in relation to immunopathological response.

Abstract:The development of hepatic fibrosis and portal hypertension is the principal cause of morbidity and mortality in schistosomiasis mansoni infection. Nevertheless, relatively little is known about the mechanisms that lead to excessive collagen deposition during infection with Schistosoma mansoni. In the murine model, infection leads to significant egg-induced granuloma formation, tissue eosinophilia, and hepatic fibrosis. Pathology has been linked to type 2 immunological responses.To evaluate the effect of praziquantel on endogenous IL-12 and its subsequent immunomodulatory effect on granuloma formation, the immune response to S. mansoni  infected mice was studied  both with and without treatment. Serum levels of IL-12 was estimated at weeks 4, 8, 12, 16 and 20  post infection in both treated and untreated mice groups.Egg count/gm tissue (liver and intestine) was calculated and oogram of the intestine was used to determine the number of immature and mature eggs in the same groups.Finally, histopathologic examination of liver was done at the same time intervals to correlate the serum levels of IL-12 with the granuloma formation. These data revealed the important effect of praziquantel in inducing IL-12 production which has a key role in immunomodulation of granuloma induced by eggs.Also this work showed that cases with low serum IL-12 level in the acute phase of the disease are suspected to be more liable to develop the debilitating fibrogranulomatous form of the disease with subsequent fatal complications, suggesting that IL-12 level could be used as an indicator for the prognosis of the disease and might help in immunotherapeutic trials especially in cases resistant to treatment.

- Quantitative Estimation of Toxoplasma B1 Gene Using Real Time Polymerase Chain Reaction ( PCR ) in infected Symptomatic And Asymptomatic Clinical Cases

Abstract: Serological diagnosis of active Toxoplasma infection is unreliable because reactivation of latent, hidden infection is not always accompanied by changes in antibody levels, and the presence of IgM does not necessarily indicate recent infection. Data concerning the relation between the severity of infection and the parasitic load especially at human level is limited. A trial was done in this work to study the relationship between the virulence of the parasite in different clinical forms and parasitic genomic load, via SYBR® Green quantitative PCR amplification assay and primers targeting Toxoplasma B1 gene. Fluorescence signals were generated from 91 samples, which were as follow; 7 cases with congenital manifestations, 19 cases with neurological disorders, and 65 asymptomatic cases. The seven congenitally infected cases showed significantly higher parasite load (5.15x 108 to 9x 1010). Other clinical forms showed genomic concentration ranged from 1.7x 104 to 4.1x 108. Equal copy numbers of template did not produce equal parameters on derivative melting curve plots. In conclusion, quantitative polymerase chain reaction (PCR) provides a sensitive and practical method not only for gene quantification, but also for gene scanning by melting curve analysis which is highly recommended for different Toxoplasma genes especially those with known pathological functions.

 Keywords: Toxoplasma- Real time polymerase chain reaction (PCR)-B1 gene-clinical forms.